GWAS signals across the HLA regions: revealing a clue for common etiology underlying infectious tumors and other immunity diseases / 癌症
Chinese Journal of Cancer
;
(12): 226-230, 2011.
Article
in English
| WPRIM
| ID: wpr-296292
ABSTRACT
Increasing evidence suggests that multiple genes in the human leukocyte antigen(HLA) regions play an important role in development of cancers and immunity disorders. However, the biological mechanisms of the HLA associations are not well understood. We recently conducted a survey of all genome-wide association studies (GWAS) with significant findings in the HLA regions and concluded that diseases such as cancer and immune disorders are more likely to be associated with genetic variants located in the HLA regions than other diseases. This finding is suggestive for testing a hypothesis of a common etiology of infectious tumors and other immunity diseases.
Full text:
Available
Index:
WPRIM (Western Pacific)
Main subject:
Genetic Variation
/
Virology
/
Lymphoma, Non-Hodgkin
/
Nasopharyngeal Neoplasms
/
Herpesvirus 4, Human
/
Genetic Predisposition to Disease
/
Allergy and Immunology
/
Genome-Wide Association Study
/
Genetics
/
HLA Antigens
Type of study:
Etiology study
Limits:
Humans
Language:
English
Journal:
Chinese Journal of Cancer
Year:
2011
Type:
Article
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