Your browser doesn't support javascript.
loading
Nasal metastases from renal cell carcinoma are associated with Memorial Sloan-Kettering Cancer Center poor-prognosis classification / 癌症
Chinese Journal of Cancer ; (12): 144-148, 2011.
Article in English | WPRIM | ID: wpr-296303
ABSTRACT
Unusual sites of metastases are recognized in patients with renal cell carcinoma (RCC). However, the prognostic implications of these sites are not well understood. We used the Memorial Sloan-Kettering Cancer Center (MSKCC) risk classification for metastatic RCC to evaluate 912 consecutive patients with RCC managed at the Singapore General Hospital between 1990 and 2009. Among these patients, 301 had metastases either at diagnosis or during the course of illness. Nasal metastases, all arising from clear cell RCC, were identified histologically in 4 patients (1.3% of those with metastasis). All 4 patients were classified as MSKCC poor prognosis by current risk criteria. Nasal metastases were significantly associated with lung and bone metastases. The frequency of nasal metastases in patients with metastatic RCC is about 1%, occurring predominantly in patients with clear cell RCC. Nasal metastases are associated with poor prognosis as estimated by the MSKCC risk classification, with attendant implications for selection of targeted therapy, and are usually associated with multi-organ dissemination, including concurrent lung and bone involvement.
Subject(s)
Full text: Available Index: WPRIM (Western Pacific) Main subject: Pathology / Pyrroles / Skull Neoplasms / Therapeutics / Bone Neoplasms / Diagnostic Imaging / Carcinoma, Renal Cell / Tomography, X-Ray Computed / Nose Neoplasms / Therapeutic Uses Type of study: Diagnostic study / Prognostic study Limits: Female / Humans / Male Language: English Journal: Chinese Journal of Cancer Year: 2011 Type: Article

Similar

MEDLINE

...
LILACS

LIS

Full text: Available Index: WPRIM (Western Pacific) Main subject: Pathology / Pyrroles / Skull Neoplasms / Therapeutics / Bone Neoplasms / Diagnostic Imaging / Carcinoma, Renal Cell / Tomography, X-Ray Computed / Nose Neoplasms / Therapeutic Uses Type of study: Diagnostic study / Prognostic study Limits: Female / Humans / Male Language: English Journal: Chinese Journal of Cancer Year: 2011 Type: Article