TMSG-1 and its roles in tumor biology / 癌症
Chinese Journal of Cancer
;
(12): 697-702, 2010.
Article
in English
| WPRIM
| ID: wpr-296367
ABSTRACT
TMSG-1 is a newly discovered tumor metastasis suppressor gene, which plays important roles in promoting apoptosis and inhibiting invasion and metastasis of tumor cells. The inhibitory function of TMSG-1 in tumor cells may be related to vacuolar H+-ATPase and ceramide, but the underlying mechanism remains unknown. Studies on TMSG-1 are limited worldwide, and only a research group in Shanghai and our group have recently studied on it. As a new research field, the function of TMSG-1 remains to be explored. This review discusses the discovery of TMSG-1, structure of its encoded protein, its roles and possible mechanism in inhibiting tumor invasion and metastasis.
Full text:
Available
Index:
WPRIM (Western Pacific)
Main subject:
Pathology
/
Pharmacology
/
Phosphorylation
/
Physiology
/
Cell Cycle
/
Ceramides
/
Apoptosis
/
Vacuolar Proton-Translocating ATPases
/
Tumor Suppressor Proteins
/
Enzyme Activation
Limits:
Animals
/
Humans
Language:
English
Journal:
Chinese Journal of Cancer
Year:
2010
Type:
Article
Similar
MEDLINE
...
LILACS
LIS