Analysis of pathogenic features and infection status of human parainfluenza virus type 3 among children in Hangzhou / 中华预防医学杂志
Chinese Journal of Preventive Medicine
;
(12): 255-260, 2016.
Article
in Chinese
| WPRIM
| ID: wpr-296592
ABSTRACT
<p><b>OBJECTIVE</b>To determine the level of genetic variation of human parainfluenza virus type 3 (HPIV-3), and to describe infection and co-infection characteristics of HPIV-3 in children.</p><p><b>METHODS</b>Single respiratory samples from 856 pediatric patients with acute respiratory tract infection (ARI) in Hangzhou were collected from December 2009 to March 2013. All samples were screened for HPIV-3 by real-time RT-PCR and followed by HN sequencing and phylogenetic analysis. In all RSV positive specimens, we screened for the other pathogens, and co-infection characteristics were evaluated.</p><p><b>RESULTS</b>A total of 9.6% of 856 samples were positive for HPIV-3, the nucleotide among the strains ranged from 96.9% to 100%. All Hangzhou strains were placed in C3 subgroup based on HN gene analysis. 49% (n=41) of all HPIV-3-positive children with ARI were found to be co-infected with at least one of the other pathogen. The highest co-infection rate of HPIV-3 was with HRV (n=17). Children in the younger groups (≤12 months old) were significantly more prone to be co-infected with other pathogen (χ(2)=4.78, P=0.029). Pneumonia infection rate was significantly higher in the mono-infection group than the co-infection group (χ(2)=3.92, P=0.048).</p><p><b>CONCLUSION</b>HPIV-3 was an important pathogen in children with ARI in Hangzhou. HN gene variation rate was low, but showed a more local pattern. The co-infections with other respiratory viruses were popular. Except for pneumonia, no significant differences in other clinical presentation between the HPIV-3 mono-infection and co-infection groups were observed.</p>
Full text:
Available
Index:
WPRIM (Western Pacific)
Main subject:
Respirovirus Infections
/
Phylogeny
/
Respiratory Tract Infections
/
Genetic Variation
/
Virology
/
China
/
Epidemiology
/
Parainfluenza Virus 3, Human
/
Real-Time Polymerase Chain Reaction
Limits:
Child
/
Humans
Country/Region as subject:
Asia
Language:
Chinese
Journal:
Chinese Journal of Preventive Medicine
Year:
2016
Type:
Article
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