Biocompatibility of a novel biological piezoelectric ceramic to the rat periosteum derived osteoblast / 华西口腔医学杂志
West China Journal of Stomatology
;
(6): 133-136, 2008.
Article
in Chinese
| WPRIM
| ID: wpr-296696
ABSTRACT
<p><b>OBJECTIVE</b>A novel biological piezoelectric ceramic was made by beta-tricalcium phosphate (beta-TCP) and lithium sodium potassium niobate (LNK) piezoelectric ceramics. To study its biocompatibility to osteoblast isolated from the cranium of 1-day-old Sprague-Dawley mice.</p><p><b>METHODS</b>The biological piezoelectric ceramic TCPLNK1/10, TCPLNK5/5 respectively mixed by beta-TCP and LNK piezoelectric ceramic at the ratio of 1/10 and 5/5. Then osteoblasts were used and seeded respectively on the negative and positive surfaces of TCPLNK1/10 and TCPLNK5/5. Growth and proliferation of the osteoblasts on TCPLNK1/10 and TCPLNK5/5 surfaces were evaluated in vitro by means of scanning electron microscopy (SEM) examination, fluorescence dyeing of osteoblast skeleton protein and MTT assay.</p><p><b>RESULTS</b>Cell morphology of osteoblast on positive and negative surfaces of TCPLNK1/10 and TCPLNK5/5 was normal, and both adhesion and growth characteristics showed better than control group. The growing osteoblasts on the TCPLNK1/10 negative surface were significantly higher than others. The negative surface of TCPLNK1/10 possessed better osteogenesis potential than others in vitro.</p><p><b>CONCLUSION</b>The surface of TCPLNK may permit the imitation piezoelectric effect of natural bone for bone regeneration.</p>
Full text:
Available
Index:
WPRIM (Western Pacific)
Main subject:
Osteoblasts
/
Osteogenesis
/
Oxides
/
Periosteum
/
Skull
/
Bone and Bones
/
Bone Regeneration
/
Calcium Phosphates
/
Microscopy, Electron, Scanning
/
Ceramics
Limits:
Animals
Language:
Chinese
Journal:
West China Journal of Stomatology
Year:
2008
Type:
Article
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