A study on the effect of the chitosan thermosensitive hydrogel loading recombinant human bone morphogenetic protein-2 on repairing periodontal defects / 华西口腔医学杂志
West China Journal of Stomatology
;
(6): 23-26, 2008.
Article
in Chinese
| WPRIM
| ID: wpr-296725
ABSTRACT
<p><b>OBJECTIVE</b>To observe the effect of the chitosan thermosensitive hydrogel loading recombinant human bone morphogenetic protein-2 (rhBMP-2) on repairing periodontal defects.</p><p><b>METHODS</b>To prepare artificial furcation defects model in the posterior area in 3 healthy male dogs, and then to inject chitosan thermosensitive hydrogel loading of rhBMP-2 after fast suturing tissue flap. The groups filled with nothing or filled only with chitosan thermosensitive hydrogel were the controls. The dogs were sacrificed after 5 weeks and the periodontal regeneration was observed histologically.</p><p><b>RESULTS</b>The histological observation showed that the chitosan thermosensitive hydrogel loading rhBMP-2 group achieved apparent periodontal tissue regeneration occupying the majority of the defects and the control groups got only a small amount of periodontal tissue regeneration.</p><p><b>CONCLUSION</b>The chitosan thermosensitive hydrogel loading rhBMP-2 can effectively promote the periodontal tissue regeneration, while simplifying the surgical operation. It might be a potential means for periodontal regeneration.</p>
Full text:
Available
Index:
WPRIM (Western Pacific)
Main subject:
Regeneration
/
Recombinant Proteins
/
Transforming Growth Factor beta
/
Bone Morphogenetic Proteins
/
Hydrogel, Polyethylene Glycol Dimethacrylate
/
Chitosan
/
Bone Morphogenetic Protein 2
Type of study:
Prognostic study
Limits:
Animals
/
Humans
/
Male
Language:
Chinese
Journal:
West China Journal of Stomatology
Year:
2008
Type:
Article
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