Discoidin domain receptors (DDRs) expression in pathological scar fibroblast formation / 中华整形外科杂志

ABSTRACT

<p><b>OBJECTIVE</b>To explore the role of discoidin domain receptors (DDRs) in the formation of the keloid.</p><p><b>METHODS</b>The real-time quantitative PCR was used to compare the DDRs expression in the keloids and normal fibroblasts.</p><p><b>RESULTS</b>The level of DDR1 expression was significantly higher in keloid than in normal fibroblast (20.98 vs 4.2, P <0.01; 7.9 vs 4.23, P <0.05). The level of DDR1 expression in keloid was also higher significantly than that in hypertropic scar (20.98 vs 7.9, P < 0.01). However, the level of DDR2 expression was somewhat higher in keloid than in normal fibroblasts, the difference seemed not to be significantly in probability (358, 332 vs 278, P > 0.05).</p><p><b>CONCLUSIONS</b>DDRs may exert effect on keloid cell behaviours.</p>