Expression and significance of TRAIL protein and mRNA in hemangioma / 中华整形外科杂志
Chinese Journal of Plastic Surgery
;
(6): 93-96, 2007.
Article
in Chinese
| WPRIM
| ID: wpr-297090
ABSTRACT
<p><b>OBJECTIVE</b>To detect the expression of TRAIL protein and mRNA in hemangiomas and vascular malformations.</p><p><b>METHODS</b>Sections of 33 proliferative hemangiomas,28 involuting hemangiomas and 29 vascular malformations were immunostained for TRAIL protein, TRAIL mRNA was examined by in situ hybridization in these tissue.</p><p><b>RESULTS</b>The TRAIL protein positive rates in proliferative hemangiomas, involuting hemangiomas, vascular malformations and normal skins were respectively 45.45% (15/33), 78.57% (22/28), 0% and 0%. There were significant differences among the four pathologies (P < 0.01). The difference between proliferative hemangiomas and involuting hemangiomas was also significant (P < 0.01). The TRAIL mRNA positive rates were 66.67% (11/33), 89.29 (25/28), 0% and 0% respectively. There were also significant differences among the four pathologies (P < 0.01). The difference between proliferative hemangiomas and involuting hemangiomas was also significant (P < 0.01).</p><p><b>CONCLUSIONS</b>TRAIL could induce endothelial apoptosis and cause regression of hemangiomas.</p>
Full text:
Available
Index:
WPRIM (Western Pacific)
Main subject:
Pathology
/
RNA, Messenger
/
In Situ Hybridization
/
Apoptosis
/
TNF-Related Apoptosis-Inducing Ligand
/
Vascular Malformations
/
Genetics
/
Hemangioma
/
Metabolism
/
Microcirculation
Limits:
Female
/
Humans
/
Male
/
Infant, Newborn
Language:
Chinese
Journal:
Chinese Journal of Plastic Surgery
Year:
2007
Type:
Article
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