A tissue response to the titanium alloy (Ti-13Zr-6Nb) in vivo / 대한치과보철학회지
The Journal of Korean Academy of Prosthodontics
;
: 619-627, 2004.
Article
in English
| WPRIM
| ID: wpr-29710
ABSTRACT
STATEMENT OF PROBLEM:
Mechanisms of tissue-implant interaction and the effect of the implant surface on the behavior of cells has not yet been clarified.PURPOSE:
This study was performed to investigate the tissue reaction to the titanium alloy submerged into rat peritoneum in vivo. MATERIALS ANDMETHODS:
Titanium alloys (titanium-13Zirconium-6Niobium) were inserted inside the peritoneal cavity of Sprague Dawley rats. After 3 months, the tissue formed around the inserted titanium alloys were examined with a light-microscope. Tissue reaction around the material was analyzed by confocal microscopy to evaluate their biocompatibility in a living body.RESULTS:
In in vivo study, foreign body type multinucleated giant cells were found in the fibrous tissue formed as a reaction to the foreign material (4 in 20 cases), but the inflammatory reaction was very weak. After experiment, the contaminants of biomaterials was removed from living tissue. In confocal microscopy, we observed that the staining of vinculin and actin showed mixed appearance. In a few cases, we found that the staining of vinculin and beta-catenin showed the prominent appearance.CONCLUSION:
We found that titanium-13Zirconium-6Niobium alloy was an excellent biomaterial.
Full text:
Available
Index:
WPRIM (Western Pacific)
Main subject:
Peritoneal Cavity
/
Peritoneum
/
Titanium
/
Biocompatible Materials
/
Giant Cells
/
Actins
/
Vinculin
/
Rats, Sprague-Dawley
/
Microscopy, Confocal
/
Alloys
Limits:
Animals
Language:
English
Journal:
The Journal of Korean Academy of Prosthodontics
Year:
2004
Type:
Article
Similar
MEDLINE
...
LILACS
LIS