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Expressions of TGF-betaR I, Smad2, Smad3 and Smad7 in keloids / 中华整形外科杂志
Chinese Journal of Plastic Surgery ; (6): 368-370, 2006.
Article in Chinese | WPRIM | ID: wpr-297138
ABSTRACT
<p><b>OBJECTIVE</b>To investigate the expression of TGF-betaR I, Smad2, Smad3 and Smad7 in keloids, normal scars and normal skins. Discuss the significance of these proteins in the course of keloid.</p><p><b>METHODS</b>Immunohistochemistry method was used to detect the expression intensity and distribution of these proteins in above 3 kinds of different tissues in 44 cases. Statistics was used to analyze the data.</p><p><b>RESULTS</b>The expression of TGF-betaR I were much stronger in keloid than in the other two tissues. The expression of Smad7 were lower in keloids. The increase expression of Smad2,3 were not obvious, but they were found to accumulate in the nucleus.</p><p><b>CONCLUSIONS</b>The results indicate that over-expression of TGF-betaR I, low-expression of Smad7 and accumulation of Smad2,3 may be one of the etiological factors of keloids. This research may provide a new idea to prevent and treat keloids or other fibrosis diseases in the future.</p>
Subject(s)
Full text: Available Index: WPRIM (Western Pacific) Main subject: Protein Serine-Threonine Kinases / Receptors, Transforming Growth Factor beta / Smad7 Protein / Smad2 Protein / Smad3 Protein / Keloid / Metabolism Limits: Adolescent / Adult / Female / Humans / Male Language: Chinese Journal: Chinese Journal of Plastic Surgery Year: 2006 Type: Article

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Full text: Available Index: WPRIM (Western Pacific) Main subject: Protein Serine-Threonine Kinases / Receptors, Transforming Growth Factor beta / Smad7 Protein / Smad2 Protein / Smad3 Protein / Keloid / Metabolism Limits: Adolescent / Adult / Female / Humans / Male Language: Chinese Journal: Chinese Journal of Plastic Surgery Year: 2006 Type: Article