Research advances in pharmacogenomics of mercaptopurine / 中国当代儿科杂志
Chinese Journal of Contemporary Pediatrics
;
(12): 1027-1033, 2017.
Article
in Chinese
| WPRIM
| ID: wpr-297161
ABSTRACT
Mercaptopurine is a common chemotherapeutic drug and immunosuppressive agent and plays an important role in the treatment of acute lymphoblastic leukemia and inflammatory bowel disease. It may cause severe adverse effects such as myelosuppression, which may result in the interruption of treatment or complications including infection or even threaten patients' lives. However, the adverse effects of mercaptopurine show significant racial and individual differences, which reveal the important role of genetic diversity. Recent research advances in pharmacogenomics have gradually revealed the genetic nature of such differences. This article reviews the recent research advances in the pharmacogenomics and individualized application of mercaptopurine.
Full text:
Available
Index:
WPRIM (Western Pacific)
Main subject:
Pharmacogenetics
/
Polymorphism, Genetic
/
Pyrophosphatases
/
Therapeutic Uses
/
Drug Therapy
/
Precursor Cell Lymphoblastic Leukemia-Lymphoma
/
Genetics
/
Mercaptopurine
/
Metabolism
/
Methyltransferases
Limits:
Humans
Language:
Chinese
Journal:
Chinese Journal of Contemporary Pediatrics
Year:
2017
Type:
Article
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