Advances in targeted therapy for childhood acute myeloid leukemia / 中国当代儿科杂志
Chinese Journal of Contemporary Pediatrics
;
(12): 832-836, 2017.
Article
in Chinese
| WPRIM
| ID: wpr-297199
ABSTRACT
At present, acute myeloid leukemia (AML) accounts for about 15%-20% of childhood acute leukemia. Although overall survival rate is increasing with the help of risk stratification, stratification of chemotherapy, and supportive treatment, conventional pharmacotherapy still has a limited clinical effect and certain limitations in improving remission rate in previously untreated patients and reducing recurrence after remission. With the development of precision medicine, the mechanisms of targeted therapy, including abnormal activation of AML-related signaling pathways and epigenetic modification, have been found in recent years. Molecular-targeted drugs can therefore act on specific receptors and target genes to improve clinical effect and the prognosis of AML patients.
Full text:
Available
Index:
WPRIM (Western Pacific)
Main subject:
Leukemia, Myeloid, Acute
/
Mortality
/
Epigenesis, Genetic
/
Drug Therapy
/
Molecular Targeted Therapy
/
Immunotherapy
Type of study:
Prognostic study
Limits:
Child
/
Humans
Language:
Chinese
Journal:
Chinese Journal of Contemporary Pediatrics
Year:
2017
Type:
Article
Similar
MEDLINE
...
LILACS
LIS