Risk factors for congenital heart disease in Chinese neonates: a Meta analysis / 中国当代儿科杂志
Chinese Journal of Contemporary Pediatrics
;
(12): 754-758, 2017.
Article
in Chinese
| WPRIM
| ID: wpr-297214
ABSTRACT
<p><b>OBJECTIVE</b>To investigate the major risk factors for congenital heart disease (CHD) in Chinese neonates and to provide a reference for the prevention of CHD.</p><p><b>METHODS</b>A literature search was performed to collect the case-control studies on the risk factors for CHD in Chinese neonates published in 2001-2016. The relevant data were extracted accordingly. The quality of included studies was assessed by Newcastle-Ottawa Scale. Sensitivity analysis was conducted using different models to analyze the same data. The publication bias was assessed by Egger's test.</p><p><b>RESULTS</b>A total of 17 case-control studies involving 2 930 cases and 4 952 controls were included. The Meta analysis showed that the major risk factors for CHD in Chinese neonates were as follows mother with advanced age (OR=2.649, 95%CI 1.675-4.189), cold or fever (OR=4.558, 95%CI 2.901-7.162), medication use in early pregnancy (OR=3.961, 95%CI 2.816-5.573), passive smoking (OR=2.766, 95%CI 1.982-3.859), abnormal childbearing history (OR=2.992, 95%CI 1.529-5.856), noise exposure (OR=3.030, 95%CI 1.476-6.217), radiation exposure (OR=2.363, 95%CI 1.212-4.607), decoration (OR=4.979, 95%CI 3.240-7.653), gestational diabetes (OR=5.090, 95%CI 3.132-8.274), and pet raising (OR=2.048, 95%CI 1.385-3.029).</p><p><b>CONCLUSIONS</b>Mothers with advanced age, cold or fever, medication use in early pregnancy, passive smoking, abnormal childbearing history, noise exposure, radiation exposure, decoration, gestational diabetes, and pet raising may increase the risk of CHD in Chinese neonates.</p>
Full text:
Available
Index:
WPRIM (Western Pacific)
Main subject:
Case-Control Studies
/
Risk Factors
/
Heart Defects, Congenital
Type of study:
Etiology study
/
Observational study
/
Prognostic study
/
Risk factors
/
Systematic reviews
Limits:
Humans
/
Infant, Newborn
Language:
Chinese
Journal:
Chinese Journal of Contemporary Pediatrics
Year:
2017
Type:
Article
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