Clinicopathologic and radiologic features of dysembryoplastic neuroepithelial tumors / 中华病理学杂志
Chinese Journal of Pathology
;
(12): 566-568, 2005.
Article
in Chinese
| WPRIM
| ID: wpr-297290
ABSTRACT
<p><b>OBJECTIVE</b>To study the clinicopathologic features and radiologic findings of dysembryoplastic neuroepithelial tumor (DNT).</p><p><b>METHODS</b>The clinical presentations, radiologic findings, histologic features and immunophenotype of 9 cases of DNT were analyzed.</p><p><b>RESULTS</b>The age of patients ranged from 12 to 51 years (mean age = 32 years). Most presented with partial seizures, sometimes accompanied by transient aphasia, agraphia and decreased visual acuity. One case was asymptomatic and discovered incidentally during a routine check-up. All patients had no neurological deficit found on physical examination. All tumors were located in the supratentorial cerebral cortex. There was no peritumoral edema or space-occupying effect on radiologic examination. The tumors involved either frontal lobe (number = 4), temporal lobe (number = 4), frontoparietal lobe (number = 1) . Two cases showed cystic changes. Two histologic variants of DNT were recognized simple (number = 3) and complex (number = 6). Simple variant was composed mainly of the glioneuronal element, accompanied by surrounding oligodendrocyte-like cells, and the complex variant contained a low-grade glioma component, in addition to the glioneuronal element and sometimes foci of cortical dysplasia.</p><p><b>CONCLUSIONS</b>DNT is a benign tumor with excellent prognosis after surgical excision. Local recurrence is rare. Complex variant of DNT needs to be distinguished from other types of low-grade glioma.</p>
Full text:
Available
Index:
WPRIM (Western Pacific)
Main subject:
Pathology
/
General Surgery
/
Brain Neoplasms
/
Magnetic Resonance Imaging
/
S100 Proteins
/
Cerebral Cortex
/
Oligodendroglia
/
Survival Rate
/
Follow-Up Studies
/
Synaptophysin
Type of study:
Observational study
/
Prognostic study
Limits:
Adolescent
/
Adult
/
Child
/
Child, preschool
/
Female
/
Humans
/
Male
Language:
Chinese
Journal:
Chinese Journal of Pathology
Year:
2005
Type:
Article
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