Influence of prenatal alcohol exposure on retinal development and cell differentiation / 生理学报
Acta Physiologica Sinica
;
(6): 505-512, 2013.
Article
in Chinese
| WPRIM
| ID: wpr-297544
ABSTRACT
The aim of the present study was to investigate the effects of prenatal alcohol exposure (PAE) on the development and cell differentiation of retina in offspring. The mouse model of PAE was made. HE staining and immunofluorescent labeling were carried out to visualize the structure, development and cell differentiation of the retina from postnatal day 0 (P0)-P30 offspring. The results showed that PAE can lead to the retardation of retinal development, the reduction of number of bipolar cells and horizontal cells, the disorder of horizontal cells' polarity, as well as the retinal thickening in a dose-dependent manner. The data suggest that alcohol exposure during pregnancy can lead to the developmental retardation of retina and decreased number of bipolar cells and horizontal cells in the retina of offspring.
Full text:
Available
Index:
WPRIM (Western Pacific)
Main subject:
Prenatal Exposure Delayed Effects
/
Retina
/
Cell Differentiation
/
Cell Biology
/
Disease Models, Animal
/
Ethanol
/
Retinal Bipolar Cells
/
Retinal Horizontal Cells
Limits:
Animals
/
Pregnancy
Language:
Chinese
Journal:
Acta Physiologica Sinica
Year:
2013
Type:
Article
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