A clinical study of sertraline and vardenafil in the treatment of premature ejaculation complicated by erectile dysfunction / 中华男科学杂志
National Journal of Andrology
; (12): 610-612, 2007.
Article
in Zh
| WPRIM
| ID: wpr-297674
Responsible library:
WPRO
ABSTRACT
<p><b>OBJECTIVE</b>To evaluate the efficacy and safety of sertraline and vardenafil in the treatment of patients with concomitant erectile dysfunction (ED) and premature ejaculation (PE).</p><p><b>METHODS</b>Sixty patients with concomitant ED and PE received at our clinic of andrology were randomly divided into a vardenafil group and a sertraline group. The vardenafil group received flexible doses of vardenafil from 10 mg to 20 mg and the sertraline group 50 mg daily, both for 2 months. The differences in IIEF-5 before and after the treatment were recorded and compared, and the results of ED treatment evaluated. Intravaginal ejaculatory latency time (IELT) was recorded to evaluate the outcome of PE treatment.</p><p><b>RESULTS</b>In the vardenafil group, 24 patients had their ED improved and the efficacy rate was 80%, as compared with 27% in the sertraline group. There was significant difference between the two groups (P < 0.05). Twenty patients had their PE improved in vardenafil group, with an efficacy rate of 67% as compared with 40% in the sertraline group. The difference was significant between the two groups (P < 0.05). In both of the two groups, a significantly higher rate of PE improvement was found in patients with improved ED than in those without. Only mild side effects were recorded, and none withdrew from the treatment.</p><p><b>CONCLUSION</b>To patients with concomitant ED and PE, the key to the treatment is to improve their erectile function, and for this purpose, vardenafil works better than sertraline.</p>
Full text:
1
Index:
WPRIM
Main subject:
Phosphodiesterase Inhibitors
/
Piperazines
/
Sulfones
/
Triazines
/
Treatment Outcome
/
Selective Serotonin Reuptake Inhibitors
/
Sertraline
/
Therapeutic Uses
/
Drug Therapy
/
Ejaculation
Limits:
Adult
/
Humans
/
Male
Language:
Zh
Journal:
National Journal of Andrology
Year:
2007
Type:
Article