Relationship between DNA repair gene XRCC1 Arg399Gln polymorphism and susceptibility to prostate cancer in the Han population in Jiangsu and Anhui / 中华男科学杂志
National Journal of Andrology
;
(12): 327-331, 2007.
Article
in Chinese
| WPRIM
| ID: wpr-297731
ABSTRACT
<p><b>OBJECTIVE</b>To investigate the association of XRCC1 Arg399Gln polymorphism, smoking and drinking with the risk of prostate cancer (PCa) in the population of Han nationality in Jiangsu and Anhui.</p><p><b>METHODS</b>A case-control study including 207 PCa patients and 235 age-matched controls was conducted. The polymorphisms of XRCC1 Arg399Gln sites were analyzed by polymerase chain reaction-restriction fragment length polymorphism (PCR-RFLP) technique using genomic DNA isolated from peripheral blood lymphocytes. We compared the correlations between the susceptibility to PCa and different genotypes, and investigated the effect of smoking and drinking.</p><p><b>RESULTS</b>The heterozygous Arg/Gln genotype was associated with statistically significantly increased risk of PCa (OR = 1.55, 95% CI 1.01-2.39) compared with those with Arg/Arg wild-type homozygote. An increased susceptibility to PCa was shown to be associated with the 399Gln allele (either the heterozygous Arg/Gln or the homozygous Gin/Gln genotypes, OR = 1.61, 95% CI 1.07-2.44) , and heavy smokers (smoking index; > or =20) (OR = 1.94, 95% CI 1.02-3.71) and superficial smokers (taking smoke into the mouth only) (OR = 2.44, 95% CI 1.02-5.80) with 399Gln allele demonstrated a significantly increased risk in comparison with those carrying wild genotype.</p><p><b>CONCLUSION</b>XRCC1 Arg399Gln polymorphism might contribute to the susceptibility to PCa. The Arg/Gln and Gln/Gln genotypes might increase the risk of PCa and have synergistic effect with smoking.</p>
Full text:
Available
Index:
WPRIM (Western Pacific)
Main subject:
Polymorphism, Genetic
/
Prostatic Neoplasms
/
Polymorphism, Restriction Fragment Length
/
Ethnicity
/
Case-Control Studies
/
China
/
Polymerase Chain Reaction
/
Epidemiology
/
Genetic Predisposition to Disease
/
DNA-Binding Proteins
Type of study:
Observational study
/
Risk factors
Limits:
Aged
/
Aged80
/
Humans
/
Male
Country/Region as subject:
Asia
Language:
Chinese
Journal:
National Journal of Andrology
Year:
2007
Type:
Article
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