The Effects of Topical Agent (Kelo-Cote or Contractubex) Massage on the Thickness of Post-Burn Scar Tissue Formed in Rats
Archives of Plastic Surgery
;
: 697-704, 2013.
Article
in English
| WPRIM
| ID: wpr-29774
ABSTRACT
BACKGROUND:
We conducted an experimental study to compare the effect of massage using topical agents (Kelo-cote or Contractubex) on scar formation by massaging the healed burn wound on the dorsal area of Sprague-Dawley (SD) rats.METHODS:
Four areas of second degree contact burn were made on the dorsal area of each of 15 SD rats, using a soldering iron 15 mm in diameter. After gross epithelialization in the defect, 15 SD rats were randomly divided into four groups the Kelo-cote group, Contractubex group, Vaseline group, and control group. Rats in three of the groups (all but the Control group) were massaged twice per day for 5 minutes each day, while those in the Control group were left unattended. For histologic analysis, we performed a biopsy and evaluated the thickness of scar tissue.RESULTS:
In the Kelo-cote and Contractubex groups, scar tissue thicknesses showed a significant decrease, compared with the Vaseline and control groups. However, no significant differences were observed between the Kelo-cote and Contractubex groups. In the Vaseline group, scar tissue thicknesses showed a significant decrease, compared with the control groups.CONCLUSIONS:
The findings of this study suggest that massage using a topical agent is helpful in the prevention of scar formation and that massage only with lubricant (no use of a topical agent) also has a considerable effect, although not as much as the use of a topical agent. Thus, we recommend massage with a topical agent on the post-burn scar as an effective method for decreasing the scar thickness.
Full text:
Available
Index:
WPRIM (Western Pacific)
Main subject:
Petrolatum
/
Wound Healing
/
Wounds and Injuries
/
Biopsy
/
Burns
/
Plant Extracts
/
Heparin
/
Cicatrix
/
Cicatrix, Hypertrophic
/
Drug Combinations
Limits:
Animals
Language:
English
Journal:
Archives of Plastic Surgery
Year:
2013
Type:
Article
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