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Relationship between phthalates and testicular dysgenesis syndrome / 中华男科学杂志
National Journal of Andrology ; (12): 195-200, 2007.
Article in Chinese | WPRIM | ID: wpr-297756
ABSTRACT
Recent epidemiological evidence demonstrates that boys born to women exposed to phthalates during pregnancy have an increased incidence of cryptorchidism, hypospadias, testicular cancer and spermatogenic dysfunction, which are collectively referred to as testicular dysgenesis syndrome (TDS). TDS may be attributed to the dysfunction of Leydig cells and Sertoli cells during their differentiation after exposure to phthalates in utero. Fox example, Leydig cell functions are significantly affected by phthalates, leading to the decrease of two Leydig cell products--insulin-like growth factor 3 (INSL3) and testosterone, which are critical factors for testis descent. The disorientation of Leydig cells and Sertoli cells in the adult testis may be the cause of spermatogenic dysfunction.
Subject(s)
Full text: Available Index: WPRIM (Western Pacific) Main subject: Phthalic Acids / Syndrome / Testicular Diseases / Testis / Epidemiology / Maternal Exposure / Cryptorchidism / Cell Biology / Toxicity / Fetus Limits: Adult / Female / Humans / Male / Infant, Newborn / Pregnancy Language: Chinese Journal: National Journal of Andrology Year: 2007 Type: Article

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Full text: Available Index: WPRIM (Western Pacific) Main subject: Phthalic Acids / Syndrome / Testicular Diseases / Testis / Epidemiology / Maternal Exposure / Cryptorchidism / Cell Biology / Toxicity / Fetus Limits: Adult / Female / Humans / Male / Infant, Newborn / Pregnancy Language: Chinese Journal: National Journal of Andrology Year: 2007 Type: Article