Genome sequencing and genetic analysis of a natural reassortant H5N1 subtype avian influenza virus possessing H9N2 internal genes / 病毒学报
Chinese Journal of Virology
;
(6): 298-304, 2010.
Article
in Chinese
| WPRIM
| ID: wpr-297866
ABSTRACT
AbstractOne H5N1 subtype avian influenza virus, A/duck/Shandong/009/2008 (Dk/SD/009/08), was isolated from apparently healthy domestic ducks in some live bird market in East China during our epidemiological surveillance. To investigate the genetic composition, Dk/SD/009/08 was subjected to genome sequencing. The amino acid motif of cleavage site was "PLRERRRK-R/GL", which was consistent with the characterization of the HPAIV. According to the newest unified nomenclature system of H5N1, Dk/SD/ 009/08 was classified into Clade 2.3.4. The BLAST results showed that four gene segments (HA, NA, NP and NS) had the highest nucleotide identities with H5N1 subtype AIVs whereas the remaining four (PB2, PB1, PA and M) displayed the closest relationship with H9N2 subtype. Therefore, Dk/SD/009/08 might be a natural reassortant virus. The phylogenetic analysis further indicated that G1-like H9N2 subtype AIVs which was prevalent mainly in quails of Southern China might provide the internal genes for Dk/ SD/009/08.
Full text:
Available
Index:
WPRIM (Western Pacific)
Main subject:
Phylogeny
/
Recombination, Genetic
/
Viral Proteins
/
Virology
/
Molecular Sequence Data
/
Reassortant Viruses
/
Classification
/
Genome, Viral
/
Influenza, Human
/
Influenza A Virus, H5N1 Subtype
Limits:
Animals
/
Humans
Language:
Chinese
Journal:
Chinese Journal of Virology
Year:
2010
Type:
Article
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