Biological characteristics of a chimeric rabies virus expressing canine parvovirus VP2 protein / 病毒学报
Chinese Journal of Virology
;
(6): 362-367, 2009.
Article
in Chinese
| WPRIM
| ID: wpr-297947
ABSTRACT
To obtain a bivalence vaccine against canine rabies virus and canine parvovirus, a chimeric rabies virus expressing canine parvovirus VP2 protein was generated by the technique of reverse genetics. It was shown that the chimeric virus designated as HEP-Flury (VP2) grew well on BHK-21 cells and the VP2 gene could still be stably expressed after ten passages on BHK-21 cells. Experiments on the mice immunized with the chimeric virus HEP-Flury (VP2) demonstrated that specific antibodies against rabies virus and canine parvovirus were induced in immunized mice after vaccination with the live chimeric virus.
Full text:
Available
Index:
WPRIM (Western Pacific)
Main subject:
Rabies
/
Rabies virus
/
Virology
/
Viral Vaccines
/
Cell Line
/
Parvovirus, Canine
/
Reverse Transcriptase Polymerase Chain Reaction
/
Capsid Proteins
/
Allergy and Immunology
/
Genetics
Limits:
Animals
Language:
Chinese
Journal:
Chinese Journal of Virology
Year:
2009
Type:
Article
Similar
MEDLINE
...
LILACS
LIS