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A new indole alkaloid from the stems of Brucea mollis / 药学学报
Acta Pharmaceutica Sinica ; (12): 225-229, 2014.
Article in Chinese | WPRIM | ID: wpr-297989
ABSTRACT
Eight compounds were isolated from the stems of Brucea mollis by various chromatographic techniques such as column chromatography on silica gel and Sephadex LH-20, and preparative HPLC, and their structures were elucidated as bruceolline O (1), 1-(1-beta-glucopyranosyl)-1H-indole-3-carbaldehyde (2), canthin-6-one (3), 11-hydroxycanthin-6-one (4), 9-methoxycanthin-6-one (5), 4-methoxycanthin-6-one (6), infractin (7), and beta-carboline-1-propionic acid (8). The cytotoxic activities of compounds 1-8 against HCT-8 and A549 human cell lines were determined, but none of them exhibited significant activity (IC 50 > 10 micromol x L(-1)). Among them, compound 1 is a new indole alkaloid, and compounds 2 and 5-7 were isolated from this plant for the first time.
Subject(s)
Full text: Available Index: WPRIM (Western Pacific) Main subject: Pharmacology / Plants, Medicinal / Carbolines / Molecular Structure / Chemistry / Plant Stems / Indole Alkaloids / Brucea / Cell Line, Tumor / Antineoplastic Agents, Phytogenic Limits: Humans Language: Chinese Journal: Acta Pharmaceutica Sinica Year: 2014 Type: Article

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Full text: Available Index: WPRIM (Western Pacific) Main subject: Pharmacology / Plants, Medicinal / Carbolines / Molecular Structure / Chemistry / Plant Stems / Indole Alkaloids / Brucea / Cell Line, Tumor / Antineoplastic Agents, Phytogenic Limits: Humans Language: Chinese Journal: Acta Pharmaceutica Sinica Year: 2014 Type: Article