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Rapid screening and quality evaluation for the harmful substance 5-hydroxymethyl furfural in commercially available traditional Chinese medicine injection using LC-MS/MS method / 药学学报
Acta Pharmaceutica Sinica ; (12): 1705-1709, 2013.
Article in Chinese | WPRIM | ID: wpr-298022
Responsible library: WPRO
ABSTRACT
To screen the harmful substance 5-hydroxymethyl furfural content in commercially available traditional Chinese medicine injection which are commonly used, and to preliminarily evaluate the quality of these injections, 5-hydroxymethyl furfural was taken as an index. The contents of 5-hydroxymethyl furfural in 56 samples which consist of 23 kinds of traditional Chinese medicine injections and glucose injection were determined using LC-MS/MS, and 5-hydroxymethyl furfural was detected in 52 of these samples. The minimal content was 0.0038 microg x L(-1) and the maximum content was 1420 microg x mL(-1). The contents of 5-hydroxymethyl furfural were significantly different in traditional Chinese medicine injection which came from different kinds, manufacturers or batches. The results showed the quality difference of commercially available traditional Chinese medicine injection is significant taking 5-hydroxymethyl furfural content as assessment index. More attention should be paid to the safety of 5-hydroxymethyl furfural in traditional Chinese medicine injection, and unified limitation standard should be set to improve medication safety of traditional Chinese medicine injection.
Subject(s)
Full text: Available Index: WPRIM (Western Pacific) Main subject: Plants, Medicinal / Drugs, Chinese Herbal / Plant Extracts / Chemistry / Chromatography, Liquid / Eleutherococcus / Drug Combinations / Tandem Mass Spectrometry / Furaldehyde / Glucose Type of study: Screening study Language: Chinese Journal: Acta Pharmaceutica Sinica Year: 2013 Type: Article

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Full text: Available Index: WPRIM (Western Pacific) Main subject: Plants, Medicinal / Drugs, Chinese Herbal / Plant Extracts / Chemistry / Chromatography, Liquid / Eleutherococcus / Drug Combinations / Tandem Mass Spectrometry / Furaldehyde / Glucose Type of study: Screening study Language: Chinese Journal: Acta Pharmaceutica Sinica Year: 2013 Type: Article