Fluorescence in-situ hybridization as a diagnostic tool for cutaneous melanoma / 中华病理学杂志
Chinese Journal of Pathology
;
(12): 37-41, 2015.
Article
in Chinese
| WPRIM
| ID: wpr-298160
ABSTRACT
<p><b>OBJECTIVE</b>To explore the utility of fluorescence in situ hybridization as a diagnostic tool for cutaneous melanoma.</p><p><b>METHODS</b>Twenty cutaneous melanomas and 20 cutaneous nevi from pathology files were selected and analyzed by Vysis melanoma FISH probe kit targeting 3 loci on chromosome 6 (MYB, CEP6 and RREB1) and 1 locus on 11q (CCND1) and data were interpreted based on the Abbott criteria provided by the kit.</p><p><b>RESULTS</b>Informative FISH results were obtained in 16 melanomas and 18 nevi. Chromosomal aberrations were detected in 12 of the 16 melanomas and only 1 of 18 nevi.</p><p><b>CONCLUSION</b>FISH is a useful diagnostic tool and able to distinguish cutaneous nevus from melanoma with good sensitivity and specificity.</p>
Full text:
Available
Index:
WPRIM (Western Pacific)
Main subject:
Skin Neoplasms
/
Chromosome Aberrations
/
Sensitivity and Specificity
/
In Situ Hybridization, Fluorescence
/
Cyclin D1
/
Diagnosis
/
Diagnosis, Differential
/
Genetics
/
Melanoma
/
Nevus
Type of study:
Diagnostic study
Limits:
Humans
Language:
Chinese
Journal:
Chinese Journal of Pathology
Year:
2015
Type:
Article
Similar
MEDLINE
...
LILACS
LIS