Correlation analysis of increased blood glucose and insulin resistance after traumatic brain injury in rats / 南方医科大学学报
Journal of Southern Medical University
;
(12): 315-317, 2007.
Article
in Chinese
| WPRIM
| ID: wpr-298176
ABSTRACT
<p><b>OBJECTIVE</b>To study the pattern of the alterations of blood glucose, insulin and insulin sensitivity after traumatic brain injury in rats, and verify the occurrence of insulin resistance after the injury.</p><p><b>METHODS</b>Based on Feeney's model of brain injury, the blood glucose and insulin concentration of the dogs measured 30 min before and at 6, 12, 24, 48, 72 and 120 h after injury. BG60-120, GIR60-120, and insulin sensitivity index (ISI) reflecting the insulin sensitivity were measured at 6, 24, 48, and 72 hours following severe traumatic brain injury using euglycemic-hyperinsulinemic clamp.</p><p><b>RESULTS</b>Both the blood glucose and insulin concentration increased markedly in rats following moderate and severe brain injury. BG60-120 increased markedly, and GIR60-120 and ISI decreased significantly 6, 24, 48, and 72 h after severe brain trauma as compared with those of the sham operation group. Blood glucose concentration of rats following severe injury was positively correlated with insulin concentration and BG60-120 at the corresponding time points, but negatively with GIR60-120 and ISI.</p><p><b>CONCLUSION</b>Both the blood glucose and insulin concentration increase markedly in rats following severe brain injury. Increased blood glucose even in the presence of high-level insulin is due to acute insulin resistance occurring after traumatic brain injury.</p>
Full text:
Available
Index:
WPRIM (Western Pacific)
Main subject:
Blood
/
Blood Glucose
/
Brain Injuries
/
Insulin Resistance
/
Rats, Wistar
/
Hyperglycemia
/
Insulin
/
Metabolism
Limits:
Animals
Language:
Chinese
Journal:
Journal of Southern Medical University
Year:
2007
Type:
Article
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