Preparation of cisplatin-impregnated coral hydroxyapatite drug delivery system / 南方医科大学学报
Journal of Southern Medical University
;
(12): 283-285, 2007.
Article
in Chinese
| WPRIM
| ID: wpr-298186
ABSTRACT
<p><b>OBJECTIVE</b>To prepare a cisplatin-impregnated coral-derived hydroxyapatite (CCHA) drug delivery system (DDS), and evaluate its inhibitory effect on human osteosarcoma cells U-2 OS, human breast cancer and prostatic carcinoma cells PC-3 in vitro.</p><p><b>METHODS</b>The coral-derived hydroxyapatite (CHA) was manufactured by hydrothermal exchange and impregnated with cisplatin by vacuum freeze-drying techniques. The leaching solutions of this DDS was collected at different intervals in a course of 8 weeks and their inhibitory effect on the cells was tested in vitro by MTT assay.</p><p><b>RESULTS</b>Electron microscope showed that cisplatin was distributed homogeneously in the pores of CHA. The inhibition rates of the leaching solution on all the tumor cells exceeded 50% except for PC-3 cells, whose inhibition rate was 29.92% when treated with the solution collected at the eighth week.</p><p><b>CONCLUSION</b>CCHA allows sustained drug release and maintains excellent inhibitory effect on human bone tumor cells within 8 weeks in vitro.</p>
Full text:
Available
Index:
WPRIM (Western Pacific)
Main subject:
Pharmacology
/
Time Factors
/
Microscopy, Electron
/
Cell Survival
/
Chemistry
/
Cisplatin
/
Drug Delivery Systems
/
Durapatite
/
Anthozoa
/
Cell Line, Tumor
Limits:
Animals
/
Humans
Language:
Chinese
Journal:
Journal of Southern Medical University
Year:
2007
Type:
Article
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