Metabolism and excretion of total flavonoids of Semen Ziziphi Spinosae in rat urine and feces / 中国中药杂志
China Journal of Chinese Materia Medica
;
(24): 340-343, 2009.
Article
in Chinese
| WPRIM
| ID: wpr-298402
ABSTRACT
<p><b>OBJECTIVE</b>To study the metabolism and excretion of total flavonoids of Semen Ziziphi Spinosae in rat urine and feces.</p><p><b>METHOD</b>The urine and feces of rats were collected at different times after orally administration of total flavonoids from Semen Ziziphi Spinosae, disposed by HP-20 macroporous resin, and then detected by both HPLC and LC-MSn methods.</p><p><b>RESULT</b>Two main proto-drugs, spinosin and 6'"-feruloylspinosin, along with a metabolite, swertish (M1), are detected in both urine and feces of rat.</p><p><b>CONCLUSION</b>Flavonoids of Semen Ziziphi Spinosae are excreted in urine and feces mainly in form of proto-drug, while little in form of metabolites, such as swertish.</p>
Full text:
Available
Index:
WPRIM (Western Pacific)
Main subject:
Semen
/
Urine
/
Flavonoids
/
Chemistry
/
Chromatography, High Pressure Liquid
/
Rats, Sprague-Dawley
/
Feces
Limits:
Animals
Language:
Chinese
Journal:
China Journal of Chinese Materia Medica
Year:
2009
Type:
Article
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