Effects of ginseng total saponins with berberine on plasma brain natriuretic peptide and Ca2+ concentration in experimental rats with chronic congestive heart failure / 中国中药杂志
China Journal of Chinese Materia Medica
;
(24): 324-327, 2009.
Article
in Chinese
| WPRIM
| ID: wpr-298406
ABSTRACT
<p><b>OBJECTIVE</b>To study the effects of total saponins of Panax ginseng combined with berberine on hemodynamics, Plasma brain natriuretic peptide and Ca2+ concentration in cardiac cells of chronic congestive heart failure rats.</p><p><b>METHOD</b>Animal models of heart failure were induced by subcutaneously injecting a large dose of ISO (80 mg x kg(-1)) for 12 days Rat and then were randomly divided into four groups model group was given distilled water by gavage; total saponins of P. ginseng combined with berberine group was treated with total saponins of P. ginseng and berberine (each 20 mg x kg(-1); once per day) taken orally; captopril group was given captopril (45 mg x kg(-1); once per day) orally; shenmai injection group was injected intraperitoneally with shenmai injection (5 mL x kg(-1), once per day). The normal control group was given distilled water by gavage. After 4 weeks of drug treatment, rat To determine the contents of hemodynamics and plasma brain natriuretic peptide were determined and rat Ca2+ concentration in cardiomyocytes was measured by flow cytometer of each group.</p><p><b>RESULT</b>Compared with normal control group, in model group can decrease the contents of LVSP, +dp/dtmax, and -dp/dtmax were decreased, but increase the contents of LVEDP, plasma brain natriuretic peptide and Ca2+ concentration were increased. The difference between two groups was significant meaning (P<0.01). Compared with model group, in total saponins of P. ginseng combined with berberine group can increase the contents of LVSP, +dp/dtmax, -dp/dtmax were increased, but were increased contents of LVEDP, plasma brain natriuretic peptide and Ca2+ concentration were decreased. The difference between two groups was significant was (P<0.01, P<0.05). Moreover, Total saponins of P. ginseng combined with berberine group had an efficacy similar to that of captopril group but superior to that of shenmai injection group.</p><p><b>CONCLUSION</b>Total saponins of P. ginseng combined with berberine has a good effect on hemodynamics, plasma brain natriuretic peptide concentration and calcium overload in experimental rats with chronic congestive heart failure.</p>
Full text:
Available
Index:
WPRIM (Western Pacific)
Main subject:
Pharmacology
/
Physiology
/
Saponins
/
Berberine
/
Blood
/
Chemistry
/
Calcium
/
Rats, Wistar
/
Natriuretic Peptide, Brain
/
Disease Models, Animal
Type of study:
Prognostic study
Limits:
Animals
Language:
Chinese
Journal:
China Journal of Chinese Materia Medica
Year:
2009
Type:
Article
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