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Study on optimization of formulation and preparation process of sinomenine liposomes / 中国中药杂志
China Journal of Chinese Materia Medica ; (24): 275-278, 2009.
Article in Chinese | WPRIM | ID: wpr-298418
ABSTRACT
<p><b>OBJECTIVE</b>To optimize the formulation and preparation process of sinomenine liposomes.</p><p><b>METHOD</b>Method of aether injection and mixture uniform design were adopted to determine the formulation of sinomenine liposomes is the proportion of phospholipids, cholesterol and Vitamin E with the index of entrapment efficiency. And the single-factor test was used to study the preparation process of the liposomes, including the volume of buffer solution, the preparation temperature and the ultrasonic time.</p><p><b>RESULT</b>The optimized formulation was that the ratio of sinomenine phospholipids cholesterol vitamin E mass ratio was 8.92 60.35 28.81 1.91. The volume of buffer solution was 50 mL x g(-1) membrane, the preparation temperature was 50 degrees C, and the ultrasonic time was 20 min.</p><p><b>CONCLUSION</b>Satisfactory shape and entrapment efficiency of the liposomes can be obtained by the optimized formulation and preparation process.</p>
Subject(s)
Full text: Available Index: WPRIM (Western Pacific) Main subject: Particle Size / Phospholipids / Drug Carriers / Pharmacokinetics / Chemistry, Pharmaceutical / Cholesterol / Technology, Pharmaceutical / Drug Delivery Systems / Dosage Forms / Drug Compounding Type of study: Health economic evaluation Language: Chinese Journal: China Journal of Chinese Materia Medica Year: 2009 Type: Article

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Full text: Available Index: WPRIM (Western Pacific) Main subject: Particle Size / Phospholipids / Drug Carriers / Pharmacokinetics / Chemistry, Pharmaceutical / Cholesterol / Technology, Pharmaceutical / Drug Delivery Systems / Dosage Forms / Drug Compounding Type of study: Health economic evaluation Language: Chinese Journal: China Journal of Chinese Materia Medica Year: 2009 Type: Article