Study on optimization of formulation and preparation process of sinomenine liposomes / 中国中药杂志
China Journal of Chinese Materia Medica
;
(24): 275-278, 2009.
Article
in Chinese
| WPRIM
| ID: wpr-298418
ABSTRACT
<p><b>OBJECTIVE</b>To optimize the formulation and preparation process of sinomenine liposomes.</p><p><b>METHOD</b>Method of aether injection and mixture uniform design were adopted to determine the formulation of sinomenine liposomes is the proportion of phospholipids, cholesterol and Vitamin E with the index of entrapment efficiency. And the single-factor test was used to study the preparation process of the liposomes, including the volume of buffer solution, the preparation temperature and the ultrasonic time.</p><p><b>RESULT</b>The optimized formulation was that the ratio of sinomenine phospholipids cholesterol vitamin E mass ratio was 8.92 60.35 28.81 1.91. The volume of buffer solution was 50 mL x g(-1) membrane, the preparation temperature was 50 degrees C, and the ultrasonic time was 20 min.</p><p><b>CONCLUSION</b>Satisfactory shape and entrapment efficiency of the liposomes can be obtained by the optimized formulation and preparation process.</p>
Full text:
Available
Index:
WPRIM (Western Pacific)
Main subject:
Particle Size
/
Phospholipids
/
Drug Carriers
/
Pharmacokinetics
/
Chemistry, Pharmaceutical
/
Cholesterol
/
Technology, Pharmaceutical
/
Drug Delivery Systems
/
Dosage Forms
/
Drug Compounding
Type of study:
Health economic evaluation
Language:
Chinese
Journal:
China Journal of Chinese Materia Medica
Year:
2009
Type:
Article
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