Studies on extraction of Ligusticum chuanxiong in Hongye Xintong soft capsule by super critical fluid extraction / 中国中药杂志

ABSTRACT

<p><b>OBJECTIVE</b>To study the rationality of extraction prosess for the Ligusticum chuanxiong in Hongye Xintong Soft Capsule by super critical fluid extraction(SFE).</p><p><b>METHOD</b>Conditions for the extraction were optimized by orthogonal experimental design as guided by the extraction rate and content of ligustilid in the extract; Combined with the experiment of rats ligated the left coronary artery, the two compounds containing different extracts (steam distillation and SFE) were compared to determine the extraction prosess.</p><p><b>RESULT</b>The best extraction conditions were established as following pressure 30 MPa, temperature 50 degrees C, extracting time 4 h, separate pressure 10 MPa. separate temperature 40 degrees C. Compared with steam distillation, the compound containing SFE extract showed stronger protective effects on rats ligated the left coronary artery.</p><p><b>CONCLUSION</b>Super critical fluid can extract active ingredients in Ligusticum chuanxiong effectively.</p>