Preparation of nanostructured lipid carriers loaded with supercritical carbon dioxide fluid extraction of Xionggui powder / 中国中药杂志
China Journal of Chinese Materia Medica
;
(24): 148-151, 2009.
Article
in Chinese
| WPRIM
| ID: wpr-298446
ABSTRACT
<p><b>OBJECTIVE</b>To study the preparation ofnanostructured lipid carriers loaded with supercritical carbon dioxide fluid extraction of Xionggui powder.</p><p><b>METHOD</b>Prepared nanostructured lipid carriers (NLC) loaded with supercritical carbon dioxide fluid extraction of Xionggui powder (XG-CO2-SFE) with a microemulsion ultrasonication method , established the best prescription of XG-CO2-SFE-NLC by orthogonal design methods with entrapment efficiency of nanoparticles as index, and investigated their physicochemical characterizations.</p><p><b>RESULT</b>The best prescription was m(phospholipid) m(S-40) m(lipid carriers) = 5 2 1, the entrapment efficiency of nanopartices was 86.8%, results revealed that nanoparticles were sphere like with the mean size of 92.6 nm and the mean zeta potential was -20.68 mV.</p><p><b>CONCLUSION</b>The prep aration method of the XG-CO2-SFE-NLC is appropriate.</p>
Full text:
Available
Index:
WPRIM (Western Pacific)
Main subject:
Powders
/
Carbon Dioxide
/
Drug Carriers
/
Drugs, Chinese Herbal
/
Linear Models
/
Chemistry
/
Chromatography, Supercritical Fluid
/
Nanostructures
/
Emulsions
/
Lipids
Language:
Chinese
Journal:
China Journal of Chinese Materia Medica
Year:
2009
Type:
Article
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