The expression of human macrophage metalloelastase mRNA in gastric cancer cell lines and tissues and its clinical significance / 中华肿瘤杂志
Chinese Journal of Oncology
;
(12): 830-832, 2007.
Article
in Chinese
| WPRIM
| ID: wpr-298501
ABSTRACT
<p><b>OBJECTIVE</b>To make measurement of the expression of HME mRNA in both gastric cancer cell lines and tissues and evaluate its role in development of gastric cancer.</p><p><b>METHODS</b>The HME mRNA expression in 3 gastric cancer cell lines and tissues was detected by real-time fluorescent quantitative PCR.</p><p><b>RESULTS</b>All three gastric cancer cell lines expressed HME mRNA, and the HME mRNA expression level in gastric cancer tissues was higher than that in normal tissues (P <0.05). The rate of lymph node metastasis of HME mRNA positive cases was lower than that of HME mRNA negative ones (P < 0.05). Expression of drug resistance gene GST of HME mRNA positive cases was lower than that of HME mRNA negative ones (P <0.05). The two-year survival rate of HME mRNA positive cases was higher than that of HME mRNA negative ones (P < 0.05). There was no correlation between the expression of HME gene and the tumor location, size, depth of invasion, degree of malignancy, expression of drug resistance gene top II and PG.</p><p><b>CONCLUSION</b>The expression of HME gene in gastric cancers may be related with lower possibility of metastasis and predict a better prognosis.</p>
Full text:
Available
Index:
WPRIM (Western Pacific)
Main subject:
Pathology
/
Stomach Neoplasms
/
RNA, Messenger
/
Survival Rate
/
Follow-Up Studies
/
Cell Line, Tumor
/
Matrix Metalloproteinase 12
/
Gastric Mucosa
/
Genetics
/
Glutathione Transferase
Type of study:
Observational study
/
Prognostic study
Limits:
Adult
/
Aged
/
Female
/
Humans
/
Male
Language:
Chinese
Journal:
Chinese Journal of Oncology
Year:
2007
Type:
Article
Similar
MEDLINE
...
LILACS
LIS