Expression and biological significance of HPA and HIF-1alpha in human esophageal squamous cell carcinoma / 中华肿瘤杂志
Chinese Journal of Oncology
;
(12): 689-692, 2007.
Article
in Chinese
| WPRIM
| ID: wpr-298517
ABSTRACT
<p><b>OBJECTIVE</b>To investigate the expression of HPA and HIF-1alpha in human esophageal squamous cell carcinoma and their relationship with cancer development, invasion and metastasis.</p><p><b>METHODS</b>The expression of HPA mRNA and HIF-1alpha protein in 23 mucosa specimens of incisal margin, 26 para-tumorous dysplastic tissues and 70 esophageal squamous cell carcinoma specimens were detected by in situ hybridization assay and immunohistochemical staining, respectively.</p><p><b>RESULTS</b>The positive expression of HPA mRNA and HIF-1alpha protein were significantly increased as the epithelial cells progressed into carcinoma (P < 0.05). The expression of HPA mRNA and HIF-1alpha protein in the esophageal squamous cell carcinoma were significantly correlated with the invasion depth, lymph node metastasis and clinical staging (P < 0.05), while it was not correlated with the differentiation of tumors (P > 0.05). There was a close correlation between the expression of HPA mRNA and HIF-1alpha protein in the carcinoma tissues (P < 0.01).</p><p><b>CONCLUSION</b>The high expression of HPA mRNA and HIF-1alpha protein is correlated with carcinogenesis, progression, invasion and metastasis of esophageal squamous cell carcinoma. There may be a positive cooperation between two of them in the carcinogenesis and development of esophageal carcinoma. The determination of HPA mRNA and HIF-1 alpha will be useful in predicting tumor biological behavior.</p>
Full text:
Available
Index:
WPRIM (Western Pacific)
Main subject:
Pathology
/
RNA, Messenger
/
Esophageal Neoplasms
/
Immunohistochemistry
/
Carcinoma, Squamous Cell
/
Gene Expression Regulation, Neoplastic
/
In Situ Hybridization
/
Esophagus
/
Hypoxia-Inducible Factor 1, alpha Subunit
/
Genetics
Type of study:
Prognostic study
Limits:
Adult
/
Aged
/
Female
/
Humans
/
Male
Language:
Chinese
Journal:
Chinese Journal of Oncology
Year:
2007
Type:
Article
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