Clinical features and prognostic factors of small breast cancer with multiple axillary lymph node metastasis / 中华肿瘤杂志
Chinese Journal of Oncology
; (12): 615-618, 2007.
Article
in Zh
| WPRIM
| ID: wpr-298536
Responsible library:
WPRO
ABSTRACT
<p><b>OBJECTIVE</b>To analyse the clinical features and prognostic factors of small breast cancer patient (T < or =2 cm) with multiple axillary lymph node metastasis (N > or =4).</p><p><b>METHODS</b>The data of 118 small breast cancer patients (T < or =2 cm) with multiple axillary lymph node metastasis (N > or =4) surgically treated from 1993 to 2003 were retrospectively analysed by SPSS 13.0 software.</p><p><b>RESULTS</b>The overall 5-year survival rate was 75.0% in this series. It was found by single-variant Kaplan-Merier analysis that the stage, adjuvant chemotherapy and adjuvant endocrine therapy significantly influenced the outcome of the patients. For patients with 4-9 or > or =10 metastatic axillary lymph nodes, the 5-year OS was 89.5% and 59.8%, respectively (P = 0.009). It was 82.1% and 53.3% in the patients with or without adjuvant chemotherapy (P = 0.001), respectively. For patients with or without adjuvant endocrine therapy, the 5-year OS was 89.2% and 61.9% (P = 0.001). Multi-variant Cox regression analysis showed that the stage, adjuvant chemotherapy and adjuvant endocrine therapy were independent prognostic factors.</p><p><b>CONCLUSION</b>Small breast cancer with multiple axillary lymph node metastasis usually has a tendency of metastasis with a poor prognosis, especially in those with > or =10 metastatic axillary lymph nodes. The stage, adjuvant chemotherapy and adjuvant endocrinetherapy were independent prognostic factors. Reasonable multi-modality therapy may be able to improve the outcome of these patients.</p>
Full text:
1
Index:
WPRIM
Main subject:
Pathology
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Axilla
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Therapeutics
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Bone Neoplasms
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Breast Neoplasms
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Proportional Hazards Models
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Survival Rate
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Retrospective Studies
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Follow-Up Studies
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Chemotherapy, Adjuvant
Type of study:
Observational_studies
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Prognostic_studies
Limits:
Adult
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Aged
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Female
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Humans
Language:
Zh
Journal:
Chinese Journal of Oncology
Year:
2007
Type:
Article