Assessment of therapeutic effect of losartan on diabetes mellitus with gas chromatography-based metabonomics / 中国医学科学院学报
Acta Academiae Medicinae Sinicae
;
(6): 719-724, 2007.
Article
in Chinese
| WPRIM
| ID: wpr-298701
ABSTRACT
<p><b>OBJECTIVE</b>To assess the therapeutic effect of losartan on type 2 diabetes mellitus (DM2) with gas chromatography (GC)-based metabonomics.</p><p><b>METHODS</b>DM2 patients were dosed with losartan (100 mg/d) and urines were collected at week 8 and 12. The biochemical criteria (blood pressure, urinary albumen, urinary 8-hydroxy-2'-deoxyguanosine and blood creatinine) were analyzed. Urine samples were derivatived and analyzed by GC. Multivariate metabonomics analysis was performed after peak alignment.</p><p><b>RESULTS</b>After 8-12 weeks, losartan showed little curative effect and no remarked changes of biochemical criteria were observed. However, metabonomics analysis revealed that some biomarkers such as glucitol and inositol changed.</p><p><b>CONCLUSION</b>GC-based metabonomics analysis enables the rapid identification of metabolic differences and provides information concerning therapeutic effect of losartan.</p>
Full text:
Available
Index:
WPRIM (Western Pacific)
Main subject:
Sorbitol
/
Urine
/
Blood
/
Biomarkers
/
Chemistry
/
Chromatography, Gas
/
Drug Monitoring
/
Losartan
/
Creatinine
/
Therapeutic Uses
Type of study:
Prognostic study
Limits:
Humans
Language:
Chinese
Journal:
Acta Academiae Medicinae Sinicae
Year:
2007
Type:
Article
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