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Assessment of therapeutic effect of losartan on diabetes mellitus with gas chromatography-based metabonomics / 中国医学科学院学报
Acta Academiae Medicinae Sinicae ; (6): 719-724, 2007.
Article in Chinese | WPRIM | ID: wpr-298701
ABSTRACT
<p><b>OBJECTIVE</b>To assess the therapeutic effect of losartan on type 2 diabetes mellitus (DM2) with gas chromatography (GC)-based metabonomics.</p><p><b>METHODS</b>DM2 patients were dosed with losartan (100 mg/d) and urines were collected at week 8 and 12. The biochemical criteria (blood pressure, urinary albumen, urinary 8-hydroxy-2'-deoxyguanosine and blood creatinine) were analyzed. Urine samples were derivatived and analyzed by GC. Multivariate metabonomics analysis was performed after peak alignment.</p><p><b>RESULTS</b>After 8-12 weeks, losartan showed little curative effect and no remarked changes of biochemical criteria were observed. However, metabonomics analysis revealed that some biomarkers such as glucitol and inositol changed.</p><p><b>CONCLUSION</b>GC-based metabonomics analysis enables the rapid identification of metabolic differences and provides information concerning therapeutic effect of losartan.</p>
Subject(s)
Full text: Available Index: WPRIM (Western Pacific) Main subject: Sorbitol / Urine / Blood / Biomarkers / Chemistry / Chromatography, Gas / Drug Monitoring / Losartan / Creatinine / Therapeutic Uses Type of study: Prognostic study Limits: Humans Language: Chinese Journal: Acta Academiae Medicinae Sinicae Year: 2007 Type: Article

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Full text: Available Index: WPRIM (Western Pacific) Main subject: Sorbitol / Urine / Blood / Biomarkers / Chemistry / Chromatography, Gas / Drug Monitoring / Losartan / Creatinine / Therapeutic Uses Type of study: Prognostic study Limits: Humans Language: Chinese Journal: Acta Academiae Medicinae Sinicae Year: 2007 Type: Article