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Recent advances in metabonomics / 中国医学科学院学报
Acta Academiae Medicinae Sinicae ; (6): 701-711, 2007.
Article in Chinese | WPRIM | ID: wpr-298703
ABSTRACT
Metabonomics (or metabolomics) aims at the comprehensive and quantitative analysis of the wide arrays of metabolites in biological samples. Metabonomics has been labeled as one of the new" -omics" joining genomics, transcriptomics, and proteomics as a science employed toward the understanding of global systems biology. It has been widely applied in many research areas including drug toxicology, biomarker discovery, functional genomics, and molecular pathology etc. The comprehensive analysis of the metabonome is particularly challenging due to the diverse chemical natures of metabolites. Metabonomics investigations require special approaches for sample preparation, data-rich analytical chemical measurements, and information mining. The outputs from a metabonomics study allow sample classification, biomarker discovery, and interpretation of the reasons for classification information. This review focuses on the currently new advances in various technical platforms of metabonomics and its applications in drug discovery and development, disease biomarker identification, plant and microbe related fields.
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Full text: Available Index: WPRIM (Western Pacific) Main subject: Biomarkers / Drug Discovery / Metabolome / Metabolomics Language: Chinese Journal: Acta Academiae Medicinae Sinicae Year: 2007 Type: Article

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Full text: Available Index: WPRIM (Western Pacific) Main subject: Biomarkers / Drug Discovery / Metabolome / Metabolomics Language: Chinese Journal: Acta Academiae Medicinae Sinicae Year: 2007 Type: Article