Current advances in the mechanic studies of human papillomavirus-induced oncogenesis / 中国医学科学院学报
Acta Academiae Medicinae Sinicae
;
(6): 673-677, 2007.
Article
in Chinese
| WPRIM
| ID: wpr-298760
ABSTRACT
Human papillomavirus (HPV) is a common small DNA tumor virus that specifically infects squamous epithelial cells and causes benign or malignant epithelial lesions such as genital warts and cervical cancer. High-risk HPV is detected in specimens of more than 90% of cervical cancer. In the 7. 9 kb genome of HPV, E6 and E7 are the crucial viral oncoproteins that consistently maintained after viral integration into host cell genome. These two proteins interfere with cell proliferation and differentiation through interacting with important tumor suppressors including p53 and pRb. High-risk HPV E6/E7 also induces genomic instability, facilitating cell transformation.
Full text:
Available
Index:
WPRIM (Western Pacific)
Main subject:
Papillomaviridae
/
Pathology
/
Physiology
/
Virology
/
Cell Differentiation
/
Cell Transformation, Neoplastic
/
Uterine Cervical Neoplasms
/
Oncogene Proteins, Viral
/
Papillomavirus Infections
/
Genomic Instability
Limits:
Female
/
Humans
Language:
Chinese
Journal:
Acta Academiae Medicinae Sinicae
Year:
2007
Type:
Article
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