Relationship between human papillomavirus 16 infection and the expression of p33(ING1b), human telomerase reverse transcriptase in cervical squamous cell carcinoma of Uygur female in Xinjiang Uygur Autonomous Region / 中国医学科学院学报

ABSTRACT

<p><b>OBJECTIVE</b>To explore the relationship between human papillomavirus (HPV) 16 infection and the expression of p33(ING1b), human telomerase reverse transcriptase (hTERT) in cervical squamous cell carcinoma of Uygur Female in Xinjiang Uygur Autonomous Region.</p><p><b>METHODS</b>Polymerase chain reaction (PCR) and immunohistochemical methods were used to detect HPV16 infection and the expression of p33(ING1b) and hTERT in the normal control group (n=12), the patients with cervical intraepithelial neoplasm (CIN) (n=34), and the patients with cervical squamous cell carcinoma (SCC) (n=50).</p><p><b>RESULTS</b>In the cervical tissues of Uygur female, the HPV16 infection rate was 0 in control group, 22.2% in the CIN 1 group, 44.0% in CIN 2 & CIN 3 group, and 74.0% in SCC group (P = 0.000). The expression rate of p33(ING1b) decreased was 91.7% in control group, 77.7% in CIN 1 group, 68.0% in CIN 2 & CIN 3 group, and 36.0% in SCC group (P = 0. 000). The expression rate of hTERT was 50.0% in control group, 66.6% in CIN 1 group, 88.0% in CIN 2 & CIN 3 group, and 94.0% in SCC group (P = 0.000). In the cervical tissues of Uygur female, the HPV16 infection rate was negatively correlated with the expression of p33(ING1b) (r = -0.294, P = 0.004), and was positively correlated with the expression of hTERT (r = 0.286, P = 0.005). The expression of p33(ING1b) was negatively correlated with the expression of hTERT (r = -0.361, P = 0.000).</p><p><b>CONCLUSION</b>The infection of HPV 16 correlates with the decreased expression of p33(ING1b) and increased expression of hTERT in the cervical squamous cell carcinoma of Uygur female in Xinjiang.</p>