Possible Therapeutic Effect of Stem Cell in Atherosclerosis in Albino Rats. A Histological and Immunohistochemical Study
International Journal of Stem Cells
;
: 200-208, 2015.
Article
in English
| WPRIM
| ID: wpr-29879
ABSTRACT
BACKGROUND:
Atherosclerosis is the leading cause of death worldwide. there are no effective approaches to regressing atherosclerosis due to not fully understood mechanisms. Recently, stem cell-based therapies have held promises to various diseases, including vascular diseases.AIM:
The present study aimed at investigating the possible effect of cord blood mesenchymal stem cell (MSC) therapy on atherosclerosis. MATERIAL ANDMETHODS:
Eighty adult male albino rats were divided into control group (I), atherogenic group (II) subjected to high cholesterol fed diet (200~300 mg/kg body weight) for 12 weeks and 1.8 million units of vitamin D / kg of diet for 6 weeks. Stem cell therapy group (III) injected with stem cells in the tail vein following confirmation of atherosclerosis. Histological, Immunohistochemical and morphometric studies were performed were conducted.RESULTS:
Atherogenic group (II) showed increased aortic thickness, intimal proliferation, smooth muscle proliferation and migration. Increased area % of collagen fibers, iNOS and vimentin immunoreactions were recorded and proved morphometrically. All findings regressed on stem cell therapy.CONCLUSION:
A definite therapeutic effect of mesenchymal stem cells was found on atherosclerosis.
Full text:
Available
Index:
WPRIM (Western Pacific)
Main subject:
Stem Cells
/
Tail
/
Vascular Diseases
/
Veins
/
Vimentin
/
Vitamin D
/
Cholesterol
/
Cause of Death
/
Collagen
/
Diet
Limits:
Animals
/
Humans
/
Male
Language:
English
Journal:
International Journal of Stem Cells
Year:
2015
Type:
Article
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