Therapeutic Effect of Adipose Derived Stem Cells versus Atorvastatin on Amiodarone Induced Lung Injury in Male Rat
International Journal of Stem Cells
;
: 170-180, 2015.
Article
in English
| WPRIM
| ID: wpr-29882
ABSTRACT
BACKGROUND AND OBJECTIVES:
Amiodarone (AM), a class 3 antiarrhythmic drug, has been associated with variety of adverse effects, the most serious of which is pulmonary toxicity. Ator (A) is a statin, known for their immunomodulatory and anti-inflammatory activities. Recent studies provide evidence of potential therapeutic effect of statins on lung injury. Adipose derived stem cells (ADSCs) have shown great promise in the repair of various tissues. The present study aimed at investigating and comparing the possible therapeutic effect of A and ADSCs on AM induced lung injury in albino rats. METHODS ANDRESULTS:
34 adult male albino rats were divided into 5 groups control group (Gp I), A group (Gp II) received 10 mg/kg of A orally 6 days (d)/week (w) for 4 weeks (ws), AM group (Gp III) received 30 mg/kg of AM orally 6 d/w for 4 ws, AM&A group (Gp IV) received AM for 4ws then A for other 4 ws and AM&SCs group (Gp V) received AM for 4 ws then injected with 0.5 ml ADSCs on 2 successive days intravenously (IV). Histological, histochemical, immunohistochemical and morphometric studies were performed. Group III displayed bronchiolitis obliterans, thickened interalveolar septa (IAS) and thickened vascular wall which were proven morphometrically. Increased area% of collagen fibers and apoptotic changes were recorded. All findings regressed on A administration and ADSCs therapy.CONCLUSION:
Ator proved a definite ameliorating effect on the degenerative, inflammatory, apoptotic and fibrotic changes induced by AM. ADSCs administration denoted more remarkable therapeutic effect compared to A.
Full text:
Available
Index:
WPRIM (Western Pacific)
Main subject:
Stem Cells
/
Bronchiolitis Obliterans
/
Collagen
/
Hydroxymethylglutaryl-CoA Reductase Inhibitors
/
Lung Injury
/
Atorvastatin
/
Amiodarone
/
Lung
Limits:
Animals
/
Humans
/
Male
Language:
English
Journal:
International Journal of Stem Cells
Year:
2015
Type:
Article
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