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Influence of cationic cyclopeptide on microstructure and permeability of Caco-2 cell membrane / 药学学报
Acta Pharmaceutica Sinica ; (12): 1062-1068, 2014.
Article in Chinese | WPRIM | ID: wpr-299166
ABSTRACT
The microstructure of cationic cyclopeptide (TD-34) treated Caco-2 cell membrane was observed, and we discussed the relationship between membrane structure and insulin transmembrane permeability. Atomic force microscope (AFM) was used to observe living cell membrane in air condition and tapping mode. Results showed that the surface of Caco-2 cell membrane treated with TD-34 lost its smoothness and nearly doubled its roughness. Apparent permeability coefficients (P(app)) of insulin in Caco-2 cell monolayers increased 2.5 times. In conclusion, AFM can be used to observe microstructure of cationic cyclopeptide treated cell membrane and cationic cyclopeptide enhanced insulin delivery across Caco-2 cell membrane by increasing membrane fluidity.
Subject(s)
Full text: Available Index: WPRIM (Western Pacific) Main subject: Peptides, Cyclic / Pharmacology / Cations / Cell Membrane / Cell Membrane Permeability / Microscopy, Atomic Force / Caco-2 Cells / Insulin / Membrane Fluidity / Metabolism Limits: Humans Language: Chinese Journal: Acta Pharmaceutica Sinica Year: 2014 Type: Article

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Full text: Available Index: WPRIM (Western Pacific) Main subject: Peptides, Cyclic / Pharmacology / Cations / Cell Membrane / Cell Membrane Permeability / Microscopy, Atomic Force / Caco-2 Cells / Insulin / Membrane Fluidity / Metabolism Limits: Humans Language: Chinese Journal: Acta Pharmaceutica Sinica Year: 2014 Type: Article