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Comparison of structural characteristics and anticoagulation activity of enoxaparin sodium with different degree of 1,6-anhydro derivatives / 药学学报
Acta Pharmaceutica Sinica ; (12): 1049-1053, 2014.
Article in Chinese | WPRIM | ID: wpr-299168
ABSTRACT
The fine structure of enoxaparin sodium samples with different degree of 1,6-anhydro derivatives were analyzed with polyacrylamide gel electrophoresis, high performance liquid chromatography, ultraviolet spectroscopy, infrared spectroscopy and nuclear magnetic resonance spectroscopy. A further study of anticoagulation activity of enoxaparins was performed, including those on their inhibition activities of coagulation factor Xa (FXa) and thrombin (FIIa). The results showed that the anti-FXa and -FIIa activities of enoxaparins with different degree of 1,6-anhydro derivatives (20.0%-39.7%) with similar structure characteristics, had decreasing tendency when the degree of 1,6-anhydro derivatives increased. Especially, the anti-FXa activity was sensitive to the change of the degree of 1,6-anhydro derivatives.
Subject(s)
Full text: Available Index: WPRIM (Western Pacific) Main subject: Thrombin / Chemistry / Enoxaparin / Factor Xa Inhibitors / Anticoagulants Language: Chinese Journal: Acta Pharmaceutica Sinica Year: 2014 Type: Article

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Full text: Available Index: WPRIM (Western Pacific) Main subject: Thrombin / Chemistry / Enoxaparin / Factor Xa Inhibitors / Anticoagulants Language: Chinese Journal: Acta Pharmaceutica Sinica Year: 2014 Type: Article