Prevention against and treatment of doxorubicin-induced acute cardiotoxicity by dexrazoxane and schisandrin B / 药学学报
Acta Pharmaceutica Sinica
;
(12): 1007-1012, 2014.
Article
in Chinese
| WPRIM
| ID: wpr-299176
ABSTRACT
In this study, it is to compare the effectiveness of prevention against and treatment of doxorubicin (DOX) induced cardiotoxicity by dexrazoxane and schisandrin B (Sch B) in rats. Sprague-Dawley (SD) rats were randomly divided into the following 6 groups normal saline group, DOX group, DOX+DEX group, DOX+Sch B (80 mg x kg(-1)) group, DOX+Sch B (40 mg x kg(-1)) group and DOX+Sch B (20 mg x kg(-1)) group. The results showed that Sch B could combat the increase of myocardial enzymes in peripheral blood, decrease of the enzyme activity of myocardial tissue antioxidant enzymes and disorders of systolic and diastolic function of heart in rats intravenously injected with doxorubicin (15 mg x kg(-1)). Sch B was better than DEX in protecting rat against DOX-induced the symptoms. Sch B could protect rat against DOX-induced acute cardiomyopathy and has clinical potential applications.
Full text:
Available
Index:
WPRIM (Western Pacific)
Main subject:
Polycyclic Compounds
/
Doxorubicin
/
Rats, Sprague-Dawley
/
Lignans
/
Cyclooctanes
/
Therapeutic Uses
/
Drug Therapy
/
Dexrazoxane
/
Cardiotoxicity
/
Heart
Limits:
Animals
Language:
Chinese
Journal:
Acta Pharmaceutica Sinica
Year:
2014
Type:
Article
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