Association between the functional monoamine oxidase A gene polymorphism and aggressively driving behavior / 中华预防医学杂志
Chinese Journal of Preventive Medicine
;
(12): 321-323, 2004.
Article
in Chinese
| WPRIM
| ID: wpr-299244
ABSTRACT
<p><b>OBJECTIVE</b>This study is purposed to explore the relationship between aggressively driving behavior and functional polymorphism in the promoter region of the monoamine oxidase-A (MAOA) gene.</p><p><b>METHODS</b>A total of 348 automobile drivers were investigated with Deffenbacher's driver anger scale, driving vengeance questionnaire (DVQ) and driver aggression behavior questionnaire. Eighty-eight drivers were selected as more, medium and less aggressive group, each. Polymerase chain reaction (PCR) and 2.5% agarose gel electrophoresisi were adopted to detect the polymorphism of functional 30 bp-uVNTR in the promoter region of the X-chromosomal MAOA gene and their frequencies of varied genotypes were estimated.</p><p><b>RESULTS</b>Two alleles with 3 and 4 repeats of 30 bp-uVNTR were detected in the drivers. Among the more aggressive group, number of the allele with 3 repeats of 30 bp-uVNTR (63/88) was significantly more than that with 4 repeats (25/88) (chi(2) = 10.21, P < 0.01), and number of the allele with 4 repeats of 30 bp-uVNTR was more in the less aggressive group, indicating that persons with allele of 3 repeats of 30 bp VNTR were more aggressive in their driving than those with 4 repeats.</p><p><b>CONCLUSIONS</b>Aggressively driving behavior in drivers possibly related to their functional MAOA-uVNTR polymorphism. Effect of the gene on aggressively driving behavior should be further studied.</p>
Full text:
Available
Index:
WPRIM (Western Pacific)
Main subject:
Physiology
/
Polymorphism, Genetic
/
Psychology
/
Automobile Driving
/
Brain
/
Serotonin
/
Surveys and Questionnaires
/
Receptors, Serotonin
/
Promoter Regions, Genetic
/
Aggression
Limits:
Adult
/
Humans
/
Male
Language:
Chinese
Journal:
Chinese Journal of Preventive Medicine
Year:
2004
Type:
Article
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