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Circadian rhythm of melatonin and blood pressure changes in patients with essential hypertension / 中华心血管病杂志
Chinese Journal of Cardiology ; (12): 20-23, 2008.
Article in Chinese | WPRIM | ID: wpr-299506
Responsible library: WPRO
ABSTRACT
<p><b>OBJECTIVE</b>To observe the association between melatonin (MLT) secretion and blood pressure changes during 24 hours in hypertensive patients (HPT) with (dipping) or without (non-dipping) night time blood pressure reduction.</p><p><b>METHODS</b>The 24-hour blood pressure and urine 6-SMT (6-sulfatoxymelatonin, metabolism product of MLT in urine) in the daytime and nighttime were measured in normal control subjects (n = 20), non-dipping HPT group (n = 32) and dipping HPT group (n = 36).</p><p><b>RESULTS</b>As expected, blood pressure reduction during the night was significantly lower in non-dipping HPT group compared to control and dipping HPT groups. Nighttime 6-SMT was significantly higher than daytime 6-SMT in all groups and nighttime urine 6-SMT levels and ratio of nighttime/daytime urine 6-SMT levels were significantly lower in non-dipping HPT group compared to control and dipping HPT groups (all P < 0.01). Moreover, ratio of nighttime/daytime urine 6-SMT levels are positively correlated blood pressure reduction during nighttime (P < 0.05) in all groups.</p><p><b>CONCLUSIONS</b>Circadian rhythm of MLT secretion is maintained but nighttime MLT secretion was significantly reduced and related to disorders of circadian rhythm of blood pressure in non-dipping HPT group.</p>
Subject(s)
Full text: Available Index: WPRIM (Western Pacific) Main subject: Physiology / Urine / Blood Pressure / Aged / Female / Humans / Male / Case-Control Studies / Circadian Rhythm / Adult Language: Chinese Journal: Chinese Journal of Cardiology Year: 2008 Type: Article

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Full text: Available Index: WPRIM (Western Pacific) Main subject: Physiology / Urine / Blood Pressure / Aged / Female / Humans / Male / Case-Control Studies / Circadian Rhythm / Adult Language: Chinese Journal: Chinese Journal of Cardiology Year: 2008 Type: Article