Clinic effect of alendronate sodium treatment in osteoporosis patients with hip fracture / 中华外科杂志
Chinese Journal of Surgery
;
(12): 347-350, 2004.
Article
in Chinese
| WPRIM
| ID: wpr-299920
ABSTRACT
<p><b>OBJECTIVE</b>To assess efficacy and safety of alendronate sodium treatment in osteoporosis patients with hip fracture.</p><p><b>METHODS</b>One year randomized, double-blind clinical trial was carried out in 77 osteoporosis patients with hip fracture. The bone mineral density (BMD) in lumbar spine (L(2 - 4)), femoral neck (Neck), Wards triangle (Wards) and great trochanter (Troch) was measured by dual energy x-ray absorptiometer (DEXA).</p><p><b>RESULTS</b>In our study, alendronate sodium induced marked increases in BMD of the L(2 - 4) (7.0% +/- 13.0%), Neck (7.3% +/- 11.1%), Wards (4.6% +/- 5.9%), Troch (4.5% +/- 3.2%) (mean +/- s) versus decreases of 2.0% +/- 4.5%, -0.9% +/- 6.9%, 3.6% +/- 4.9% and 1.14% +/- 6.0% with placebo (P < 0.05). Blood Ca, P, ALP, BGP and Urine Pyd/C were no significant difference between before and after therapy. There were usually mild and transient side-effect, such as gastrointestinal symptoms.</p><p><b>CONCLUSION</b>Alendronate is an efficacy and safety drug in treatment of osteoporosis.</p>
Full text:
Available
Index:
WPRIM (Western Pacific)
Main subject:
Osteoporosis
/
Pharmacology
/
Blood
/
Absorptiometry, Photon
/
Bone Density
/
Case-Control Studies
/
Calcium
/
Double-Blind Method
/
Treatment Outcome
/
Alendronate
Type of study:
Controlled clinical trial
/
Observational study
Limits:
Aged
/
Female
/
Humans
/
Male
Language:
Chinese
Journal:
Chinese Journal of Surgery
Year:
2004
Type:
Article
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