The significance of platelet-derived endothelial cell growth factor mRNA expression in superficial bladder cancer / 中华外科杂志
Chinese Journal of Surgery
;
(12): 478-481, 2004.
Article
in Chinese
| WPRIM
| ID: wpr-299942
ABSTRACT
<p><b>OBJECTIVE</b>To investigate the mRNA expression of platelet-derived endothelial cell growth factor (PD-ECGF) in superficial bladder cancer and its significance.</p><p><b>METHODS</b>PD-ECGF mRNA expressions were determined by RT-PCR in 28 cases of superficial bladder cancers and 6 cases of normal bladder mucosa. The relation between PD-ECGF mRNA expression and tumor invasion to lamina propria or recurrence after transurethral resection was also analyzed.</p><p><b>RESULTS</b>Some degree of PD-ECGF mRNA expression was present in all the samples. The PD-ECGF mRNA level was 3.1-fold higher in pT(1) tumors than in normal bladder mucosa (t = 2.13, P < 0.05) and 2.2-fold higher in pT(1) tumors than in pT(a) tumors (t = 2.66, P < 0.05); G(3) tumors expressed 3.3-fold higher PD-ECGF mRNA than normal bladder mucosa (t = 2.44, P < 0.05) and 2.5-fold higher than G(1 - 2) tumors (t = 3.36, P < 0.01). Eleven cases recurred during the mean follow-up period of 18 months. Three-fold higher PD-ECGF mRNA expression was showed in cases who recurred after transurethral resection than that in cases who did not recur (t = 4.49, P < 0.01). The specificity and sensitivity of predicting tumor recurrence were 82.4% and 81.8% respectively using 0.095 as a cutoff value of PD-ECGF mRNA level in this group of superficial bladder cancer.</p><p><b>CONCLUSION</b>PD-ECGF mRNA expression correlates with tumor dedifferentiation and plays an important role in the early invasion in superficial bladder cancer. To analyze the PD-ECGF mRNA level contributes to the evaluations of tumor differentiation and invasion to lamina propria as well as recurrence prediction in superficial bladder cancer.</p>
Full text:
Available
Index:
WPRIM (Western Pacific)
Main subject:
Pathology
/
Thymidine Phosphorylase
/
Urinary Bladder Neoplasms
/
RNA, Messenger
/
Carcinoma, Transitional Cell
/
Follow-Up Studies
/
Reverse Transcriptase Polymerase Chain Reaction
/
Genetics
/
Metabolism
Type of study:
Observational study
/
Prognostic study
Limits:
Humans
Language:
Chinese
Journal:
Chinese Journal of Surgery
Year:
2004
Type:
Article
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