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Pulmonary artery perfusion with hypothermic solution inhibits the apoptosis of lung parenchymal cells during cardiopulmonary bypass / 中华外科杂志
Chinese Journal of Surgery ; (12): 227-229, 2004.
Article in Chinese | WPRIM | ID: wpr-299967
ABSTRACT
<p><b>OBJECTIVE</b>To study effects of pulmonary artery perfusion with hypothermic solution on the apoptosis of lung parenchymal cells during cardiopulmonary bypass.</p><p><b>METHODS</b>Forty children with tetralogy of Fallot were divided into control group (n = 20) and protective group (n = 20). The patients in control group were performed using routine approaches. Patients' pulmonary artery were infused with 4 degrees C protective solution during cardiopulmonary bypass in protective group. Lung biopsy specimens were obtained after operations in order to study the apoptosis of lung parenchymal cells using tunnel techniques. At same time, patients' pulmonary functions and clinic index were monitored.</p><p><b>RESULTS</b>The rate of apoptosis cells of lung parenchymal cells was (18 +/- 7)% in control group, whereas (10 +/- 2)% in protective group. There was significant difference between both groups (t = -2.95, P < 0.05). Index O(2) in protective group was higher than that in control group at 0, 6 and 12 hours after operations [(492 +/- 172), (444 +/- 104), (489 +/- 58) mm Hg versus (369 +/- 126), (347 +/- 107), (340 +/- 119) mm Hg, t = 2.59, P < 0.05; t = 2.88, P < 0.01; t = 5.06, P < 0.01, respectively)]. The time of mechanical ventilation was significantly shorter in protective group than in control group [(15 +/- 11) hours versus (26 +/- 15) hours, t = -2.76, P < 0.01].</p><p><b>CONCLUSION</b>Pulmonary artery perfusion with hypothermic solution can inhibit the apoptosis of lung parenchymal cells and relieve cardiopulmonary bypass-induced lung injury.</p>
Subject(s)
Full text: Available Index: WPRIM (Western Pacific) Main subject: Pathology / Perfusion / Pulmonary Artery / General Surgery / Tetralogy of Fallot / Cardiopulmonary Bypass / Case-Control Studies / Apoptosis / Hypothermia, Induced / Lung Type of study: Observational study Limits: Child, preschool / Female / Humans / Infant / Male Language: Chinese Journal: Chinese Journal of Surgery Year: 2004 Type: Article

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Full text: Available Index: WPRIM (Western Pacific) Main subject: Pathology / Perfusion / Pulmonary Artery / General Surgery / Tetralogy of Fallot / Cardiopulmonary Bypass / Case-Control Studies / Apoptosis / Hypothermia, Induced / Lung Type of study: Observational study Limits: Child, preschool / Female / Humans / Infant / Male Language: Chinese Journal: Chinese Journal of Surgery Year: 2004 Type: Article