Detection of serum levels of MMP-9 and VEGF in patients with bladder cancer / 中华外科杂志
Chinese Journal of Surgery
;
(12): 430-432, 2003.
Article
in Chinese
| WPRIM
| ID: wpr-300015
ABSTRACT
<p><b>OBJECTIVE</b>To detect serum levels of MMP-9 and VEGF in patients with bladder cancer.</p><p><b>METHODS</b>Serum levels of MMP-9 and VEGF in 58 patients with bladder cancer and 45 healthy controls were measured by sandwich-ELISA.</p><p><b>RESULTS</b>Serum levels of MMP-9 and VEGF (737.12 micro g/L and 1148.88 ng/L) were significantly higher in the cancer patients than those of controls (423.51 micro g/L and 846.96 ng/L, P < 0.01). The serum levels were associated with tumor stage and grade. In patients with invasive cancer, the levels were significantly higher than those of superficial cancer (P < 0.01). Patients with distant metastasis had significantly higher levels of MMP-9 and VEGF than those with localized invasion (P < 0.01). But there was no significant difference between patients with superficial cancer and controls. Patients with G(3) tumors had significantly higher levels of MMP-9 and VEGF than those of patients with G(1) and G(2) tumors (P < 0.01).</p><p><b>CONCLUSIONS</b>Elevated MMP-9 and VEGF levels are associated with a high stage and grade of bladder cancer and they may serve as markers of tumor progression in the future.</p>
Full text:
Available
Index:
WPRIM (Western Pacific)
Main subject:
Pathology
/
Urinary Bladder Neoplasms
/
Blood
/
Matrix Metalloproteinase 9
/
Vascular Endothelial Growth Factor A
/
Neoplasm Staging
Type of study:
Diagnostic study
Limits:
Aged
/
Humans
Language:
Chinese
Journal:
Chinese Journal of Surgery
Year:
2003
Type:
Article
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