Effect of zige lyophilized powder for injection in improving acute cerebral microcirculation disturbance in rats / 中国中药杂志
China Journal of Chinese Materia Medica
;
(24): 733-737, 2014.
Article
in Chinese
| WPRIM
| ID: wpr-300159
ABSTRACT
<p><b>OBJECTIVE</b>To investigate the effect of Zige lyophilized powder for injection in improving the acute cerebral microcirculation disturbance in rats.</p><p><b>METHOD</b>Window craniotomy was performed for rats after the drug administration for 14 days. The experimental microcirculation disturbance model was duplicated with high molecule dextran. After the drug administration, the micro-vein diameters of cerebral pla mater of various groups were observed and recorded under the biological microscope. The blood flow volume was monitored by laser Doppler flow-meter. HCT was measured by the electric resistance method. The hemorheological indexes were detected by the auto-hemorheological instrument.</p><p><b>RESULT</b>Zige lyophilized powder for injection (16.40, 32.70, 65.40 mg x kg(-1)) could significantly expand the micro-vein diameter of cerebral pla mater, improve the downward trend of the blood flow volume, and reduce the various hemorheological indexes.</p><p><b>CONCLUSION</b>Zige lyophilized powder for injection shows the effect in improving the cerebral microcirculation.</p>
Full text:
Available
Index:
WPRIM (Western Pacific)
Main subject:
Powders
/
Brain
/
Drugs, Chinese Herbal
/
Brain Ischemia
/
Cerebrovascular Circulation
/
Rats, Sprague-Dawley
/
Drug Therapy
Limits:
Animals
/
Humans
/
Male
Language:
Chinese
Journal:
China Journal of Chinese Materia Medica
Year:
2014
Type:
Article
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